California State Teachers Retirement System Biotechnology

California State Teachers Retirement System

$78.8 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
VRTX Vertex Pharmaceuticals Inc	$114B	$193 Million 0.25% of portfolio	398,483	Q1 2025 Reduced 0.55%
REGN Regeneron Pharmaceuticals, Inc.	$54.9B	$105 Million 0.13% of portfolio	166,096	Q1 2025 Reduced 1.07%
ALNY Alnylam Pharmaceuticals, Inc.	$38.5B	$53.3 Million 0.07% of portfolio	197,443	Q1 2025 Added 0.55%
RPRX Royalty Pharma PLC	$15.5B	$27 Million 0.03% of portfolio	866,406	Q1 2025 Reduced 1.13%
UTHR United Therapeutics Corp	$13B	$19.6 Million 0.02% of portfolio	63,708	Q1 2025 Added 1.16%
BMRN Biomarin Pharmaceutical Inc	$10B	$19.5 Million 0.02% of portfolio	276,178	Q1 2025 Added 0.88%
TECH Bio Techne Corp	$1.93B	$14.5 Million 0.02% of portfolio	247,860	Q1 2025 Reduced 0.6%
MRNA Moderna, Inc.	$10B	$14.1 Million 0.02% of portfolio	496,168	Q1 2025 Reduced 0.94%
INCY Incyte Corp	$15B	$13.9 Million 0.02% of portfolio	229,602	Q1 2025 Reduced 4.74%
INSM Insmed Inc	$14.3B	$12 Million 0.02% of portfolio	157,698	Q1 2025 Added 2.84%
CORT Corcept Therapeutics Inc	$7.96B	$10.3 Million 0.01% of portfolio	90,124	Q1 2025 Added 3.62%
EXEL Exelixis, Inc.	$14B	$9.07 Million 0.01% of portfolio	245,673	Q1 2025 Added 1.53%
HALO Halozyme Therapeutics, Inc.	$7.35B	$7.74 Million 0.01% of portfolio	121,300	Q1 2025 Added 2.52%
JAZZ Jazz Pharmaceuticals PLC	$6.69B	$6.75 Million 0.01% of portfolio	54,374	Q1 2025 Reduced 1.17%
TGTX Tg Therapeutics, Inc.	$5.31B	$5.34 Million 0.01% of portfolio	135,530	Q1 2025 Reduced 1.07%
SRPT Sarepta Therapeutics, Inc.	$1.65B	$5.23 Million 0.01% of portfolio	81,995	Q1 2025 Added 1.65%
BPMC Blueprint Medicines Corp	$7.67B	$5.19 Million 0.01% of portfolio	58,588	Q1 2025 Reduced 1.13%
RVMD Revolution Medicines, Inc.	$3.51B	$4.94 Million 0.01% of portfolio	139,640	Q1 2025 Added 23.54%
ADMA Adma Biologics, Inc.	$3.46B	$4.74 Million 0.01% of portfolio	238,802	Q1 2025 Added 9.85%
BBIO Bridge Bio Pharma, Inc.	$6.25B	$4.2 Million 0.01% of portfolio	121,474	Q1 2025 Added 5.03%
CYTK Cytokinetics Inc	$3.07B	$4.16 Million 0.01% of portfolio	103,512	Q1 2025 Reduced 1.15%
MDGL Madrigal Pharmaceuticals, Inc.	$4.84B	$4.09 Million 0.01% of portfolio	12,356	Q1 2025 Reduced 1.51%
PCVX Vaxcyte, Inc.	$1.97B	$4.04 Million 0.01% of portfolio	107,050	Q1 2025 Added 1.9%
IONS Ionis Pharmaceuticals Inc	$5.35B	$3.99 Million 0.01% of portfolio	132,238	Q1 2025 Reduced 1.24%
KRYS Krystal Biotech, Inc.	$3.54B	$3.63 Million 0.0% of portfolio	20,126	Q1 2025 Reduced 1.29%
ROIV Roivant Sciences Ltd.	$8.1B	$3.42 Million 0.0% of portfolio	339,385	Q1 2025 Reduced 13.36%
AXSM Axsome Therapeutics, Inc.	$4.36B	$3.41 Million 0.0% of portfolio	29,205	Q1 2025 Reduced 1.31%
PTCT Ptc Therapeutics, Inc.	$3.55B	$3.28 Million 0.0% of portfolio	64,425	Q1 2025 Reduced 1.27%
RARE Ultragenyx Pharmaceutical Inc.	$2.58B	$2.79 Million 0.0% of portfolio	76,998	Q1 2025 Reduced 1.35%
RNA Avidity Biosciences, Inc.	$1.52B	$2.65 Million 0.0% of portfolio	89,792	Q1 2025 Added 6.2%
CRNX Crinetics Pharmaceuticals, Inc.	$1.61B	$2.52 Million 0.0% of portfolio	74,997	Q1 2025 Reduced 1.66%
SWTX Spring Works Therapeutics, Inc.	$2.93B	$2.44 Million 0.0% of portfolio	55,370	Q1 2025 Reduced 1.51%
CPRX Catalyst Pharmaceuticals, Inc.	$2.27B	$2.38 Million 0.0% of portfolio	98,265	Q1 2025 Reduced 1.96%
CRSP Crispr Therapeutics Ag	$3.55B	$2.37 Million 0.0% of portfolio	69,742	Q2 2024 Added 4.53%
NUVL Nuvalent, Inc.	$3.27B	$2.33 Million 0.0% of portfolio	32,844	Q1 2025 Reduced 1.79%
RYTM Rhythm Pharmaceuticals, Inc.	$3.45B	$2.26 Million 0.0% of portfolio	42,721	Q1 2025 Reduced 1.87%
VKTX Viking Therapeutics, Inc.	$1.99B	$2.23 Million 0.0% of portfolio	92,254	Q1 2025 Reduced 1.64%
VCYT Veracyte, Inc.	$1.91B	$2.09 Million 0.0% of portfolio	70,529	Q1 2025 Reduced 1.82%
IMVT Immunovant, Inc.	$3.55B	$2.04 Million 0.0% of portfolio	74,314	Q1 2025 Added 53.54%
PTGX Protagonist Therapeutics, Inc	$2.63B	$2.02 Million 0.0% of portfolio	41,856	Q1 2025 Reduced 1.16%
VCEL Vericel Corp	$1.97B	$2.01 Million 0.0% of portfolio	45,022	Q1 2025 Reduced 1.82%
ACLX Arcellx, Inc.	$2.76B	$1.99 Million 0.0% of portfolio	30,336	Q1 2025 Reduced 2.02%
SRRK Scholar Rock Holding Corp	$1.76B	$1.99 Million 0.0% of portfolio	61,795	Q1 2025 Added 9.82%
LGND Ligand Pharmaceuticals Inc	$1.94B	$1.98 Million 0.0% of portfolio	18,797	Q1 2025 Added 10.48%
AKRO Akero Therapeutics, Inc.	$2.51B	$1.89 Million 0.0% of portfolio	46,641	Q1 2025 Reduced 0.41%
XENE Xenon Pharmaceuticals Inc.	$1.96B	$1.86 Million 0.0% of portfolio	55,492	Q2 2024 Added 4.77%
MRUS Merus N.V.	$2.42B	$1.73 Million 0.0% of portfolio	41,149	Q2 2024 Reduced 12.63%
FOLD Amicus Therapeutics, Inc.	$1.6B	$1.7 Million 0.0% of portfolio	208,565	Q1 2025 Reduced 2.2%
ACAD Acadia Pharmaceuticals Inc	$3.64B	$1.65 Million 0.0% of portfolio	99,279	Q1 2025 Reduced 2.34%
BEAM Beam Therapeutics Inc.	$1.18B	$1.62 Million 0.0% of portfolio	82,802	Q1 2025 Added 25.53%

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