State Of Wisconsin Investment Board Biotechnology

State Of Wisconsin Investment Board

$38.5 Billion
Q2 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
VRTX Vertex Pharmaceuticals Inc	$99.5B	$63.6 Million 0.17% of portfolio	142,938	Q2 2025 Reduced 6.38%
REGN Regeneron Pharmaceuticals, Inc.	$59.7B	$29.9 Million 0.08% of portfolio	57,012	Q2 2025 Reduced 14.48%
ALNY Alnylam Pharmaceuticals, Inc.	$52.9B	$25.5 Million 0.07% of portfolio	78,106	Q2 2025 Added 6.77%
TECH Bio Techne Corp	$2.07B	$12.7 Million 0.03% of portfolio	246,080	Q2 2025 Added 40.96%
INSM Insmed Inc	$16.5B	$11.9 Million 0.03% of portfolio	117,961	Q2 2025 Reduced 6.36%
BPMC Blueprint Medicines Corp	$7.73B	$11.5 Million 0.03% of portfolio	89,373	Q2 2025 Added 39.5%
UTHR United Therapeutics Corp	$13.7B	$10.3 Million 0.03% of portfolio	35,726	Q2 2025 Added 2.33%
INCY Incyte Corp	$18.2B	$8.21 Million 0.02% of portfolio	120,572	Q2 2025 Reduced 27.32%
EXEL Exelixis, Inc.	$12.1B	$8.11 Million 0.02% of portfolio	184,090	Q2 2025 Reduced 5.02%
MRUS Merus N.V.	$2.93B	$7.87 Million 0.02% of portfolio	149,543	Q2 2025 Reduced 5.54%
RPRX Royalty Pharma PLC	$15.7B	$7.2 Million 0.02% of portfolio	199,746	Q2 2025 Reduced 16.62%
BMRN Biomarin Pharmaceutical Inc	$10.6B	$6.6 Million 0.02% of portfolio	119,997	Q2 2025 Reduced 19.58%
MRNA Moderna, Inc.	$10B	$6.24 Million 0.02% of portfolio	226,145	Q2 2025 Added 19.74%
TGTX Tg Therapeutics, Inc.	$3.94B	$5.63 Million 0.01% of portfolio	156,319	Q2 2025 Reduced 12.82%
XENE Xenon Pharmaceuticals Inc.	$2.24B	$5.47 Million 0.01% of portfolio	174,850	Q2 2025 Added 79.98%
KRYS Krystal Biotech, Inc.	$3.69B	$4.96 Million 0.01% of portfolio	36,089	Q2 2025 Added 49.23%
CORT Corcept Therapeutics Inc	$7.88B	$4.29 Million 0.01% of portfolio	58,456	Q2 2025 Reduced 40.79%
HALO Halozyme Therapeutics, Inc.	$8.95B	$4.14 Million 0.01% of portfolio	79,648	Q2 2025 Reduced 5.98%
ACAD Acadia Pharmaceuticals Inc	$4.12B	$4.02 Million 0.01% of portfolio	186,361	Q2 2025 Reduced 3.24%
JAZZ Jazz Pharmaceuticals PLC	$7.1B	$3.93 Million 0.01% of portfolio	37,014	Q2 2025 Reduced 5.66%
IONS Ionis Pharmaceuticals Inc	$5.85B	$3.82 Million 0.01% of portfolio	96,694	Q2 2025 Reduced 10.73%
RVMD Revolution Medicines, Inc.	$3.09B	$3.63 Million 0.01% of portfolio	98,536	Q2 2025 Added 0.48%
BCRX Biocryst Pharmaceuticals Inc	$1.55B	$3.36 Million 0.01% of portfolio	375,249	Q2 2025 Reduced 28.96%
BBIO Bridge Bio Pharma, Inc.	$7.28B	$3.09 Million 0.01% of portfolio	71,651	Q2 2025 Reduced 6.58%
FOLD Amicus Therapeutics, Inc.	$1.96B	$2.89 Million 0.01% of portfolio	504,128	Q2 2025 Added 23.88%
RARE Ultragenyx Pharmaceutical Inc.	$1.97B	$2.82 Million 0.01% of portfolio	77,501	Q2 2025 Added 4.17%
ADMA Adma Biologics, Inc.	$3.29B	$2.73 Million 0.01% of portfolio	150,037	Q2 2025 Reduced 14.01%
MDGL Madrigal Pharmaceuticals, Inc.	$6.14B	$2.72 Million 0.01% of portfolio	8,994	Q2 2025 Reduced 20.33%
PCVX Vaxcyte, Inc.	$1.78B	$2.72 Million 0.01% of portfolio	83,574	Q2 2025 Reduced 9.88%
AXSM Axsome Therapeutics, Inc.	$4.51B	$2.7 Million 0.01% of portfolio	25,847	Q2 2025 Reduced 16.03%
CYTK Cytokinetics Inc	$3.23B	$2.64 Million 0.01% of portfolio	79,964	Q2 2025 Added 2.66%
IMVT Immunovant, Inc.	$3.55B	$2.58 Million 0.01% of portfolio	93,893	Q2 2025 Added 68.53%
ROIV Roivant Sciences Ltd.	$8.15B	$2.52 Million 0.01% of portfolio	223,219	Q2 2025 Reduced 5.96%
CRSP Crispr Therapeutics Ag	$4.42B	$2.51 Million 0.01% of portfolio	51,565	Q2 2025 Reduced 1.5%
HRMY Harmony Biosciences Holdings, Inc.	$2.1B	$2.42 Million 0.01% of portfolio	76,548	Q2 2025 Added 7.98%
PTCT Ptc Therapeutics, Inc.	$3.24B	$2.39 Million 0.01% of portfolio	48,859	Q2 2025 Reduced 26.83%
INVA Innoviva, Inc.	$1.4B	$2.34 Million 0.01% of portfolio	116,485	Q2 2025 Added 79.55%
VKTX Viking Therapeutics, Inc.	$3.06B	$2.29 Million 0.01% of portfolio	86,290	Q2 2025 Reduced 16.76%
RYTM Rhythm Pharmaceuticals, Inc.	$5.51B	$2.26 Million 0.01% of portfolio	35,708	Q2 2025 Added 8.12%
AUPH Aurinia Pharmaceuticals Inc.	$1.61B	$2.22 Million 0.01% of portfolio	262,335	Q2 2025 Reduced 18.72%
CPRX Catalyst Pharmaceuticals, Inc.	$2.09B	$2.12 Million 0.01% of portfolio	97,471	Q2 2025 Reduced 26.5%
NUVL Nuvalent, Inc.	$3.29B	$2.1 Million 0.01% of portfolio	27,556	Q2 2025 Reduced 32.25%
AGIO Agios Pharmaceuticals, Inc.	$1.94B	$1.97 Million 0.01% of portfolio	59,100	Q2 2025 Reduced 15.19%
SRPT Sarepta Therapeutics, Inc.	$1.6B	$1.89 Million 0.0% of portfolio	110,464	Q2 2025 Added 48.84%
CRNX Crinetics Pharmaceuticals, Inc.	$1.53B	$1.86 Million 0.0% of portfolio	64,587	Q2 2025 Added 1.62%
RNA Avidity Biosciences, Inc.	$2.41B	$1.85 Million 0.0% of portfolio	65,018	Q2 2025 Added 10.78%
PTGX Protagonist Therapeutics, Inc	$2.68B	$1.82 Million 0.0% of portfolio	32,988	Q2 2025 Reduced 38.62%
AKRO Akero Therapeutics, Inc.	$2.23B	$1.79 Million 0.0% of portfolio	33,546	Q2 2025 Reduced 9.68%
SRRK Scholar Rock Holding Corp	$1.66B	$1.77 Million 0.0% of portfolio	49,964	Q2 2025 Reduced 33.28%
CLDX Celldex Therapeutics, Inc.	$1.11B	$1.72 Million 0.0% of portfolio	84,726	Q2 2025 Added 143.08%

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